They are a few things that I find unacceptable that are in the recent 2012 release:

Bugs that have been reported as critical but still ignored

1) Double click edit in assembly models is ridiculously slow

2) Using a tapped hole in hole wizard toggles off "suprress features" in configured parts

3) Weldment cutlist still needs to be manully rebuild after altering weldment

4) Surfaces are still not shown in section views in the 2D concept

feel free to add to my list!