Getting a Save "Error" when working with DesignTables and resolving through a catalog in V5

This question is for V5 Users: 

When synchronizing a catalog with a designtable/MasterPart.. i sometimes get this Excel popup... Could someone explain to me what's going on and why i get this "Save" pop up window..? 
Normally i just click don't save to continue my work.. Just want to know what i do wrong.. :-)