Name: KKB Excerpt BayScreen Example

Author: Steven Muskal – Eidogen-Sertanty,

Version : 1.0

Created: 8/2007

Modified: N/A

Purpose: This example protocol screens through the first 50K of the Scitegic provided Asinex and Maybridge-sets using 6 Bayesian active-inactive models (AURKA, ABL, CDC2, EGFR, MAPK14, and SRC) built from IC50 data extracted from the Eidogen-Sertanty Kinase Knowledgebase (KKB). Models have been built for over 120 kinase targets. For more information, please contact info@eidogen-sertanty.com.

Requirements: Pipeline Pilot 6.1.1 (collections: Chemistry)

O/S: PP Server Windows and Linux
PP Client Windows

Limitations: None

Keyword: Kinase QSAR Screening

Contents:

KKB-Excerpt-BayScreen-Example.xml
ABL_ALL.xml
AURKA_ALL.xml
CDC2_ALL.xml
EGFR_ALL.xml
MAPK14_ALL.xml
SRC_ALL.xml

Installation: Drag the *_ALL.xml QSAR models from the appropriate ExcerptModels-6.* folder into the Pipeline Pilot client explorer “LearnedProperties” folder. Drag the protocol into the Pipeline Pilot client workspace, or drag/drop into one of the Pipeline Pilot client explorer tabs to import it directly in the protocol database.

Please Note – Models have been built from data from Eidogen-Sertanty’s Kinase Knowledgebase (KKB) - http://www.eidogen-sertanty.com/products_kinasekb.html - Please reference Eidogen-Sertanty’s KKB database when (re)using these models.