After running Chemical Registration 2023 Configuration Wizard to create a new CHEMREG database, I was able to register one chemical structure record. I checked the underline table "CRS_CHEMISTRYDATA", it looks good . The Direct Cartridge domain index exists and is valid. Also, I was able to run this sql command: "select molfile (value) from CRS_CHEMISTRYDATA;" without any error. When I tried to register another one, I don't understand why CHEMREG throws the following error.

(Do I miss some configuration in setting up CHEMREG ?)

"ORA-29902: error in executing ODCIIndexStart() routine ORA-20100: MDL-1956: Unable to read molfile: vcMDLCtab::ReadHeader: error reading third line vcMolFromText::MolFromMDLSDFormat: Pipeline Pilot exception rethrown MDL-1622: Input string is not a valid molfile string, Chime string, gzip64 string, SMILES string, HELM string, IUPAC name, InChI string: Sci MDL-1051: Molstructure search query is not a valid molecule MDL-0976: Molecule index search initialization failed ORA-06512: at "C\$DIRECT2023.MDL_MXIXMDL", line 347 ORA-06512: at "C\$DIRECT2023.MDL_MXIXMDL", line 310 : select ea.attr_pk,e.entity_pk, 'EXACT' type from ems_entity e, ems_entity_attr ea, CRS_CHEMISTRYDATA c, ems_lifecycle l, CRS_TEMPORARY_QUERY_TABLE t where fle"

I need some help to resolve this issue. Thank you very much!