Hello,
I could not find the Bioster in the support matrix, the protocol 'Generate Bioisosteres of Known Drugs' complains "Dataset based on the full Accelrys Bioster database. This data is not included with the Bioisosteres components in Pipeline Pilot. It is available for users who have a valid license to the Bioster database. In order to use the full Bioster data, the property "BiosterDatabaseLicense" should be defined as a global in the Server. This property should contain a valid license key for the Bioster database."
Thanks!