Building a polymeric nanoparticles

Dear all,

I would like to know how to build nanoparticles from three different biodegradable polymers. I have build the polymers and now I need to blend them in form of nanoparticle. My system is organic solvent/water and also I would like to know how can I adjust an exact solvent/polymers ratio in order to simulate the same surrounding and to be able to optimize the conformation of the polymers.

Thank you in advance.

Best regards,
Simona