Why may structures fail after upgrade of CISPro and Direct?

CISPro has been upgraded from (for example) version 2020 to 2022.  BIOVIA Direct 2020 has been replaced by Direct 2022 and the Direct 2022 synonyms were setup using the command: execute c\$direct2022.mdlauxop.setup


CISPro appears to be functioning until attempting to upload a structure (mol file) to a chemical.  At this point an error occurs and the structure cannot be uploaded.


Error Message:

Invalid mol file: An internal error occurred: Error updating table identified as NodePropMol.setMol_mol_data_2_64476c36-6393-4931-b223-faa5f0236174 with the following SQL: insert into mol_data (moldataid,isdirectcompatible,jctnodepropid,nodeid,fingerprintfailed,modified,jobid,originalmol,CTAB,ORIGINALCDX) values(:moldataid,:isdirectcompatible,:jctnodepropid,:nodeid,:fingerprintfailed,:modified,:jobid,:originalmol,:CTAB,:ORIGINALCDX); the exception thrown was:ORA-29881: failed to validate indextype; Exception occurred in CswCommon: at ChemSW.RscAdo.CswDataAdapter.Update(DataTable DataTable) in C:\buildarea\cispro\Common\CswCommon\Csw\Ado\CswDataAdapter.cs:line 305 at ChemSW.DB.CswTableUpdate.update(DataTable DataTable, Boolean AllowAuditing) in C:\buildarea\cispro\Common\CswCommon\Csw\DB\CswTableUpdate.cs:line 418 at ChemSW.Nbt.PropTypes.CswNbtNodePropMol._saveMolData(String MolString, Byte[] cdxData) in C:\buildarea\cispro\nbt\nbt\NbtLogic\csw\PropTypes\CswNbtNodePropMol.cs:line 328; at ChemSW.RscAdo.CswDataAdapter.Update(DataTable DataTable) in C:\buildarea\cispro\Common\CswCommon\Csw\Ado\CswDataAdapter.cs:line 305 at ChemSW.DB.CswTableUpdate.update(DataTable DataTable, Boolean AllowAuditing) in C:\buildarea\cispro\Common\CswCommon\Csw\DB\CswTableUpdate.cs:line 418 at ChemSW.Nbt.PropTypes.CswNbtNodePropMol._saveMolData(String MolString, Byte[] cdxData) in C:\buildarea\cispro\nbt\nbt\NbtLogic\csw\PropTypes\CswNbtNodePropMol.cs:line 328;