In Workbook 2021 and later releases, we create Workbook Private and Workbook Public sites in IIS. If IIS is not installed on system C drive, workflow service fails to start. Also, Vault private Web Service page gives a compilation error.
There is a defect NBK-33459 entered for this in BIOVIA Jira system. Given below is the description. It is planned to be fixed in Workbook 2023 release.
NBK-33459: Vault Installer Should Function When IIS Root is Not On C Drive.
Workaround:
Rename the path of the Workbook Private site from '%SystemDrive%\inetpub\wwwroot' to 'Drive:\inetpub\wwwroot', ie., 'E:\inetpub\wwwroot' where E is the drive where IIS is installed.