Oracle version 12c introduced Oracle Multitenant Architecture, which implements container (CDB) and pluggable (PDB) databases. If you are using CDBs/PDBs, you must install BIOVIA Direct into a PDB. PDBs include options for keeping PDBs separate from each other. For example, PATH_PREFIX, which you can specify at PDB creation time, points to a file system path on the Oracle server that limits the PDB's file system access to that path or its subdirectories. When installing BIOVIA Direct into a PDB that has the PATH_PREFIX parameter set, the installation instructions differ from an installation into a non-CDB or a PDB without the PATH_PREFIX set. The attached document outlines the differences in the installation process.