In BIOVIA Draw libraries of the various types of sequence residue templates, like amino acids, sugars, bases etc. are managed with the Sequence Template Manager”. For the drawing of new templates this is as well a good starting point, for example with the template of glycine.
After drawing the full structure of your new template, you may place additional leaving groups in the side chain, in addition to the left and right
Finally, your template needs to be saved. In the File menu chose “Save as SCSR Template”. Enter additional data and save into the corresponding library.
Now, in order to upload your newly created templates into a Centralized Library, you go and export your templates from the Sequence template Manager dialog.
The following article describes how Centralized Libraries are created and maintained:
HELM Support in BIOVIA applications – Pipette BioSketcher
For the drawing of sequence residue templates you have the choice between the drawing of SCSR templates as described above or HELM monomers using Pipette Sketcher. Once templates are uploaded into Centralized Libraries both formats can be converted into one another. So, it is a matter of personal preference which editor to use for drawing.
To start drawing HELM monomers, launch the Pipette Sketcher Monomer Report:
https://
You may start from an existing monomer:
Make your edits and export as SD file:
After merging the downloaded SD files, the resulting file can be uploaded into a Centralized Library.
Other Community articles on HELM
- HELM Support in BIOVIA applications - Intro
- HELM Support in Pipeline Pilot
- HELM Support in BIOVIA applications – Central Libraries
- HELM Support in BIOVIA applications – Pipette BioSketcher
