On 28 November 2025, BIOVIA released BIOVIA Direct version 2026. As listed in the Product Release Document for Direct 2026, this version includes 11 new scientific calculators (DIR-4512 to DIR-4522) as well as changes and improvements to existing functions (DIR-4272 and DIR-4407). The documentation on these enhancements is not yet complete in the original Direct 2026 release.

Additionally, in the original Direct 2026 release, substructure searches with molecules with enhanced axial stereochemistry might not find all matches unless the query structure is provided as a binary chemistry object (DIR-4559).

To fix the issues listed above, BIOVIA will release the hotfix BIOVIA Direct 2026 HF1, scheduled for end of January 2026. BIOVIA recommends skipping the installation of BIOVIA Direct 2026 and installing version 2026 HF1 instead. If you aspire to install BIOVIA Direct 2026 before the release of the hotfix, please do not hesitate to contact BIOVIA Support if you have any questions or concerns about the hotfix. We are happy to assist you.