Trying to save assembly but "The Handle is Invalid" comes up

I have been working on a large assembly.  When I try to Save, I get a Solidworks warning box with the red X of death that says "The handle is invalid." with an OK button.  I hit the button and check the saving folder, but the file has not saved.  I need to save this by the end of the day ...

SolidworksAssemblies