How can you fully constrain pipe routes in a larger assembly?

Creating a large pump system skid and preparing it for Simulation.  Each of 6 route assemblies are fully constrained within the separate route assemblies.  There are no route components that have ( - ) indicators, yet the assembly does?  When editing the route no components can be moved.  When closing the route assembly I can click on any of the routes and move them.  All routes are connected to fully constrained components (pumps, pipe supports, chillers, etc) all of which are fully constrained.

I can "FIX" each route, but am concerned that this may affect the Simulation run.

Any help is very appreciated!

Art

SolidworksAssemblies