Changing Settings

A co-worker has SolidWorks 10 SP2.1 32bit machine.  Once a week his machine keeps defaulting back to factory settings.  This means that he is loosing pointers to a modified toobox, templates, and common file storage location.  There are 5 other power useres who use the same settings some on 32 bit some on 64 bit and we have had no issues.  Any ideas

SolidworksToolbox