At what speed the air compressibility starts having effect on the car hydrodynamic performance ?

Some new sports model cars (exclusing racing cars) can speed above 250 mph? - To improve the hydrodynamics we have to be aware at what speed (Raynolds number based on average/maximum hight of the car) the compresibility cannot be neglected for drag, lift- and down-force. Does anyone have experience in such tyupe of CFD analysis or knows the answer?

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