I've just run into an example where the Minimize Molecule (in 7.5.2) component flips the chirality of a molecule. The molecule has 3D coordinates, but no chiral flag or enhanced stereochemistry assigned. Is this a known bug in 7.5.2? Has anyone else seen this?
I can't show the molecule for proprietary reasons, unfortunately. And chopping off pieces so that only the core remains prevents the problem from happening.