I have been discussing with people on the need of Components and Protocols in the field of Population Pharmacokinetic-Pharmacodynamic (PKPD) Modelling and Simulation. I would like to gather here links to different works and needs of population pharmacokineticists, in order to develop a proper set of tools within Pipeline Pilot. Please share your needs and thoughts.

Forum Protocols and Components

• NONMEM Model View, an example of how to handle, parse and report NONMEM Files with Pipeline Pilot in an interactive and intuitive way
  
  
• Run WinBUGS Script, an example of how to run a WinBUGS model Script within Pipeline Pilot. It is integrated using the R package R2WinBUGS and the Pipeline Pilot R-Statistics collection
  
  
• Digitise Categorical Data, useful if your software only accepts numbers as category values

Software

• The NONMEM Project has been concerned with the development of data analysis techniques and exportable software for estimating the parameters of nonlinear mixed effects (statistical regression-type) models. Integration Prototype available on the forum
  
  
• The BUGS (Bayesian inference Using Gibbs Sampling) project is concerned with flexible software for the Bayesian analysis of complex statistical models using Markov chain Monte Carlo (MCMC) methods. Integration Prototype available on the forum
  
  
• WinNonlin provides an easy-to-use Windows application for PK, PK/PD, and noncompartmental analysis. WinNonlin includes extensive libraries of PK and PKPD models, and provides tools for table generation, scripting, and data management. Integration Prototype
  
  
• Monolix is a free software dedicated to the analysis of non linear mixed effects models. The objective of this software is to perform: Parameter estimation, Model selection, Goodness of fit plots, Data simulation. Integration To Be Done
  
  
• R is 'GNU S', a freely available language and environment for statistical computing and graphics which provides a wide variety of statistical and graphical techniques: linear and nonlinear modelling, statistical tests, time series analysis, classification, clustering, etc. The Comprehensive R Archive Network (CRAN) presents the following CRAN Task View: Analysis of Pharmacokinetic Data. Bayesian estimation methods for panel data are also available and described in the CRAN Task View for Bayesian Inference. Released more information on the R-Statistics collection
  
  
• etc, etc.

Events

2011

• Accelrys will attend the 2011 PAGE Meeting in Athens, Greece, on June 7-10 2011. PAGE is a group of individuals  with a common interest in data analysis using the population approach. [Abstract]

2010

• Accelrys attended the 2010 PAGE Meeting in Berlin, Germany, on June 8-11 2010. PAGE is a group of individuals with a common interest in data analysis using the population approach. [Abstract]
  
  
• Accelrys attended the 6th International Symposium on Measurement and Kinetics of In Vivo Drug Effects in Noordwijkerhout (near Leiden), The Netherlands, on April 21-24 2010. As with the previous symposia in 1990, 1994, 1998, 2002, and 2006, the purpose is to bring together scientists with an interest in in vivo Pharmacodynamic investigations to discuss the latest developments in the field of PKPD modelling.

2009

• Accelrys attended the 2009 PKUK in Birmingham, UK, on November 25-27 2009. PKUK is an open forum for discussing all PKPD issues in drug development as well as clinical implications of PKPD studies.
  
  
• Accelrys attended the 2009 PAGE Meeting in St. Petersburg, Russia, on June 23-26 2009. PAGE is a group of individuals with a common interest in data analysis using the population approach. [Abstract]