I have a core and 2 Rgroups that are aligned in 3D, say 10 different R1 and 10 different R2, hence the full matrix would be 100 but the available compounds are only 20.

I can from the 20 molecules derive the 10 R1 and 10 R2, I can enumerate all 100 but the coordinates get lost in the default 'enumerate using Rgroups' is there a way to fix this?

Kind regards,

Christophe Buyck