Can I do small molecules search using molecular descriptors (2D/3D descriptors) which are derived from QSAR studies?

The QSAR analysis identifies potential molecular descriptors for the experimental value. Based on QSAR studies, the molecules of interest are modified or new molecules are designed for a further level of experimentation.

Now, I would like to find the molecules from the small database using molecular descriptors based search. Is this possible with BIOVIA Pipeline Pilot?