Dear all,

I used AMBER to run MD simulation all the time. The most commonly used force field for water was TIP3P. I knew it's possible to use script to apply TIP3P water in Materials Studio, but I don't want to do that.

I want to try the MS force field for water. From the help files, cvff seems a choice for water since it said "The consistent-valence forcefield (cvff), the original forcefield provided with the Discover program, is a generalized valence forcefield (Dauber-Osguthorpe et al., 1988). Parameters are provided for amino acids, water, and a variety of other functional groups.".

Is cvff a common choice for water in MS? Are universal or other force fields available for water?

Thanks,

Xiaoquan.