Hi All,

  Thnak you for your valuable time.

   I am usign MS (Polymorph Predictor Module) to predict Polymorphs of some Pharmaceutical active compounds.

  Here my question follows.

Before launching the polymorph prediction job i do some conformer searching using Conformer tool, and select the generated conformer molecule with least energy and use this as Input for the Polymorph prediction searching all avaliable space groups (P1, P212121,....).

After Successful completion of the Polymorph Prediction i get some output, i take the lowest energy molecule and visualise it and calculate it possible hydrogen bond contacts.

Now i have no idea that the predicted polymorph is relaible one or not? ( Is there any method / tool where i can alteast get some impression that my predicted polymorph is some thing reliable one or purely waste of computation energy)?

Can any one suggest me what is the next step i should do after the polymorph prediction?

Should i also predict the polymorphs of all generated conformers?

Thanks

Tati