In Forcite module, it has 'annealing' option and one can change following parameters.

(1) Annealing cycle

(2) Initial temperature

(3) Mid-cycle temperature

(4) Heating steps per ramp

(5) Dynamic steps per ramp

I have a question but how can I choose/optimize these parameters to obtain a global minimum?

Is following example can trusted or there is something to think about?

[Examples I have found]

6 Hexapyropheophorbide a-fullerene [C60] molecules as part of modular carrier systems

(Step 1) Geometry optimization was carried out by specifying forcefield.

(Step 2) The molecules were heated to 700K and then cooled to 300K over a period of 1000fs for up to 500 cyles.

(Step 3) After each annealing cycle geometry optimization was executed to obtain the energetically minimized conformation.

(Step 4) The structures with the lowest potential energy were selected for analysis.