This script calculates the free volume using solvent surfaces for a defined range of frames in a trajectory. A study table is created with the frame number and the total free volume for that frame. Optionally, you can also segregate the field into isolated segregates. From this, you can calculate the number of segregates, and minimum, maximum, and mean volume for each segregate.

You can do a lot more analysis using segregates but this is a first, fairly simple script. Please feel free to extend and re-post this.

Modules: Materials Visualizer
Minimum version: Materials Studio 4.3

Please note that I have not included a trajectory with this MaterialsScript document.

Cheers

Stephen