Seeking Help for solvation

Dear All,
DS provides us a protocol for solvating a protein. However, the solvent could only be TIP3 water. Is it possible that my protein could be solvated with different kind of solvent(e.g.isobutane)?
Further more, is it possible for me to firstly build a water layer around the protein, and then solvated the whole system with another kind of solvant?