I have a protein with 4 domains and strc of all 4 domains are avalbale in PDB, but separately. The complete strc of the protein is not available in PDB. Between domains there are 3 loops whose strc is absent in PDB. So I want to combine all 4 domains and 3 loops , to get the full protein. Now, can anyone tell me hw can I do that. I dont think homology modeling can be done bcoz, those loops are missing in templates. Ab initio modeling seems to be not reliable enough in my case. Can I use ab initio technique and simultaneously specify the known domain templates so that some parts will be based on homolgy and the remaining will be created ab initio ???