Hi all,
I want to use MCSS to predict new inhibitor molecules using fragments availbale. I have question:
1. I want to use those framents obtained from already known inhibitors , is it reasonable?
2. when i try docking some fragments, all fragments were found to be docked outside the defined sphere, please tell me where i am going wrong in protocol?
3. After generating few possible fragments, how can i connect them to generate complete molecules (whats methods can i use)..
You advice will be helpful to my work...
Thank you
with regards,
vamsi