I recently read an article that discovered a new CK2 receptor binding site αD site and designed a new CK2 inhibitor CAM4066 through FBDD. I want to repeat the research of this article in silico. I want to use Ludi to connect two fragments, but neither De Novo Link nor De Novo Evolution failed. I refer to the answer to this question. can DS2.1 search fragment database to link two scafflods in binding site of receptor
The link I used from this article: A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066
(https://www.sciencedirect.com/science/article/pii/S0968089616314791).
The attchment is the document I used.
