Hi all

I have two molecules in a molecular window separated from each other and my interest is to make them interact with each other. So i added distance restraints to make them come near each other and interact. I had applied a distance restraint of [Max: 3.6A and min: 2.5A], but after simulation, i see that the molecules have moved far apart [distance is 16-20 A]. Pls let me know as how to apply the distance constraints and do a simulation.

I am attaching a file containing the two ligands that was used in the simulation