Hii everybody,
I am using DS 2.0 in windows platform. I am trying to generate a common feature pharmacophore (HipHop) using 5 molecules as input.In the spreadsheet file i am assigning three molecules as active with "Principal" value 2 and "MaxOmitFeat" value 0. The other two molecules are assigned inactive with "Principal" value 0 and "MaxOmitFeat" value 2. The common feature pharmacophore generated at this setting contains the mapping and fit value of the active molecules only, the inactive molecules are not mapped in the generated pharmacophore. How it can be solved? I have attached the hiphop log file. The molecules 99 and 138 are inactive. Thanks in advance.