Hello,

I am a relatively new user and have been trying to use Discovery Studio for designing a mutation library. In essence this requires me to run some docking in Discovery Studio and see where there are problem residues in my protein. I have already identified several candiates for mutation but I am struggling in interpreting actual figures that the docking protocols throw up. For example if I run a docking protocol on my Wt protein and then one on a mutant, both with the same substrate, what figures do I use to tell me which poses are the more successful? There are various energy calculations the protocols give me but I need help in interpreting these numbers into something meaningful.

Thanks in advance for any help.

jwaller1989