This article describes about the novel classification system for enzymes that is  based on sequence based descriptors and pharmacophore mapping which is  done with Discovery Studio pacakge. The full article citation is given  below and can be downlaoded at

http://dx.doi.org/10.1016/j.biotechadv.2010.09.003

Udatha,  D.B.R.K.G.; Kouskoumvekaki, I.; Olsson, L; Panagiotou, G. The interplay  of descriptor-based computational analysis with pharmacophore modeling  builds the basis for a novel classification scheme for feruloyl  esterases. Biotechnol Adv 2011; 29(1):94-110.