De Novo Fragment design

Hello all,

I have a task i would like someone to help me with; i have been at it for several months now but i can't seem to make any headway.

:designing novel ligands using the fragment-based approach (de novo) that can bind to binding site (highlighted in yellow).

I have uploaded the files; the target protein (the aa that consititute the binding site are highlighted in yellow), and the small library of

fragments that i used; please feel free to use any other library as you may see fit.

many thanks,

Martis.