I am trying to generate a representive group of conformers for an average-large sized drug that features a ring.(MW~400). I have the following modules: DS Standalone, CHARMm, Biopolymer, and Analysis, and thus cannot use FAST, BEST, or CAESAR. Is there a way using the Systematic, Random, and/or Boltzmann Jump search to generate conformers that also change the dihedral angles in the ring? From what I understand these protocols only change defined rotatable bonds - or those that can be defined by the program - which does NOT include bonds in the ring. (I tried generating conformers of cyclohexane in the chair conformer, results in only 1 conformation: the original chair conformer).