Hi,

So far, I have found the Enumerate Library by ligand and reaction protocols to be very useful. I am running in to some problems though as far as chirality goes.

If I have a core structure (enumerate by ligand), I want to modify and R-group that is not at all associated with a chiral center. So I prepare the structure with either R or S, and then add the ligands. Sometimes though, this chiral center gets inverted which ruins my library.

Is there a way to control this better? Another similar problem is also with the enumerate by reaction which actually does involve the chiral center. Unfortunately it seems inconsistent as far as which chiral form it likes to take.


Thanks
-Daniel