Hello everyone. i am new to the community and DS. My issue is that I am getting very high negative CDocker energies and Interaction enrgy values. accoring to pre discussed issue on this, i should take this result as not good binding and a weak interaction between the ligand and receptor. However, since i am in running this as only a control test on the ligand and receptor upon reports from literature, i dont understand how to interpret this result. the literature reports this as a good result. the other problem is negative CDocker energy and positinve interaction energy. According to previous discussion this should mean good interaction  between receptor and ligand but overall high energy leading to destabilization. Is that correct? Another issue is ofcourse 0 poses in the reported active site.

Kindly help.

regards

ayesha