One week away from now we will have to defend our thesis already, and I just found out that what I've been working on has already been done by other researchers I am now trying to find allosteric inhibitors for the DENV NS5 RNA dependent RNA polymerase, and I have found a journal that mentions the target site/cavity for the allosteric inhibitors. I am hoping to do pharmacophore modelling but I don't know if it's possible without a known inhibitor. Can I just select the residues mentioned in the journal, generate a site sphere from there and base my pharmacophore on that? Thank you so much..