Hello Pipeline Pilot Chemistry / SDK and Direct users. We are considering a change to the atom hybridization perception for the following Nitrogen and Oxygen examples and we want your feedback.

The image below shows in black the existing perception for N and O in the molecules (sp2 or sp3) and the proposed new perception in red. We have proposed these changes due to the preponderance of cases where the lone pairs participate in resonance, conjugation or aromaticity, and thus should be sp2. However, when the Nitrogen is charged it should be sp3.

Do you agree?

Let us know in the comments below.