Background:
Versions 2021 of BIOVIA Direct, Pipeline Pilot Chemistry and Draw, and Pipette 3.0 and later support adding reagents to reactions.

BIOVIA Direct 2021:
Now includes an enhanced reaction format that adds representations for reagents, solvents, and catalysts.

Pipeline Pilot 2021:
Support for reagent molecules was added to the RXN and RD file formats, and the corresponding reader and writer components in Pipeline Pilot were updated to be able parse and write reagent information.

The RXN Reader component has also been updated to support RXN file format output from Nextmove and ChemAxon.

Pipeline Pilot Chemistry APIs have been updated as well to support this new feature.

Pipette 3.3.0 (from Pipeline Pilot 2021) and above now support RXN and RD file formats with reagent extensions, and supports adding and modifying reagents above and below the reaction arrow.

BIOVIA Draw 2021:
There is an example of this new feature in the BIOVIA Draw Help. Open the BIOVIA Draw Help and search for “adding reagents”. The Adding Reagents link above brings you to:

You will find instructions and see an example of a reagent, including a name and comment added to a reaction.

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