Discovery Studio tools used in rational ligand-based pharmacophore modeling to identify potential drug leads for treatment of metabolic diseases

Journal article title:

“Pharmacophore modeling and virtual screening studies for discovery of novel farnesoid X receptor (FXR) agonists”

https://pubs.rsc.org/en/content/articlelanding/2021/RA/D0RA09320C

Tools used in Discovery Studio: Common Feature Pharmacophore Generation protocol, and Ligand Profiler protocol.  Two identified highly active compounds were docked into the active site of FXR using the CDOCKER protocol.